XLSTATでKaplan-Meier 解析を実行する
ãã®ãã¥ã¼ããªã¢ã«ã¯ãXLSTATã½ããã¦ã§ã¢ãç¨ãã¦Excelå ã§ã°ã«ã¼ãæ¯è¼ãå«ãã«ãã©ã³-ãã¤ã¤ã¼åæ ãã»ããã¢ãããã¦è§£éããæ¹æ³ã示ãã¾ãã
Kaplan-Meier è§£æãå®è¡ãããã¼ã¿ã»ãã
ãã¼ã¿ã¨çµæã®Excelã·ã¼ãã¯ã以ä¸ã®ãã¿ã³ãã¯ãªãã¯ãã¦ãã¦ã³ãã¼ãã§ãã¾ãï¼ ãã¼ã¿ããã¦ã³ãã¼ã
ãã¼ã¿ã¯ [Gehan E.A. (1965). A generalized Wilcoxon test for comparing arbitrarily singly-censored samples. Biometrika, 52, pp 203?223] ã§å¾ããããã®ã§ãç¡ä½çºåè¨åºè©¦é¨ã§acute leukemiaï¼æ¥æ§ç½è¡ç ï¼ã®æ£è ã®æ²éæéï¼é±ï¼ã§ã®6-ã¡ã«ã«ããããªã³è¬ã®å¹æã調æ»ãã¦ãã¾ãã
ãã®Kaplan-Meierè§£æã®ç®ç
æã ã®ç®çã¯ãè¬ãçåæéã«å½±é¿ãããã© ãããã21人ã®2群ã®çåæ²ç·ãæ¯è¼ãã¦æ±ºå®ãããã¨ã§ãã1ã¤ã®ç¾¤ã¯æ²»çãæ½ããããã1ã¤ã®ç¾¤ã¯ã³ã³ããã¼ã«ã»ã°ã«ã¼ãã§ããã³ã³ããã¼ã«ã»ã°ã«ã¼ãã®21人ãã¹ã¦ ã®æ£è ã¯ãç½è¡ç ã®åçºããããã¨ã観å¯ããã¾ããã6-MPæ£è ã®9人ã ãåçºæéã観å¯ããã䏿¹ä»ã®12人ã¯è¦³å¯ãæã¡åããã¾ããã
Kaplan-Meier è§£æã®ã»ããã¢ãã
XLSTATãéãã¦ãXLSTATï½**çåæéåæ**ï½**Kaplan-Meierè§£æ**ã³ãã³ãã鏿ãããã
ãã¿ã³ãã¯ãªãã¯ããã¨ãKaplan-Meierè§£æ ãã¤ã¢ãã°ã»ããã¯ã¹ãç¾ãã¾ããExcelã·ã¼ãä¸ã§ãã¼ã¿ã鏿ãã¦ãã ããã
**æéãã¼ã¿**ã¯æ£è ãåçºãããæã¡åããããã®ããããã®æéã«å¯¾å¿ãã¾ãã
**ç¶æ ã¤ã³ã¸ã±ã¼ã¿**ã¯ãä»»æã®æéã§æ£è ãåçºããã (ã¤ãã³ãã»ã³ã¼ã=1) ããããæã¡åãããã(æã¡åãã³ã¼ã = 0)ãè¨è¿°ãã¾ãã

 ãã¼ã¿ã»ãªãã·ã§ã³ ã¿ãã§ã**ã°ã«ã¼ããã¨ã®åæ**ãæå¹ã«ãã¦ããã¼ã¿ã»ãã£ã¼ã«ã§ã°ã«ã¼ãæ å ±ã鏿ãã¦ãã ãããããã¨XLSTATã¯ãæ£è ãã³ã³ããã¼ã«ãæ²»çãã©ã¡ãã«å±ãããã®æ å ±ãèæ ®ã«å ¥ããããã«ãªãã¾ããæ¯è¼æ¤å®ãè¨ç®ãããããã«ã**æ¯è¼**ãªãã·ã§ã³ãæå¹ã«ãã¦ãã ããã**ãã£ã«ã¿**ãªãã·ã§ã³ã¯ãåæãå®è¡ãããã°ã«ã¼ããå³å¯ã«é¸æãããã¨ãã§ãã¾ãã

**ãã£ã¼ã**ã¿ãã§ã¯ã表示ãããããã£ã¼ããæå¹ã«ãã¦ã**æã¡åããã¼ã¿**ã表ç¾ããã®ã«ä½¿ç¨ãããè¨å·ãé¸ãã§ãã ããã

OKãã¯ãªãã¯ããã¨è¨ç®ãå§ã¾ãã¾ããããã¦æ°ããExcel ã·ã¼ãã«çµæã表示ããã¾ãã
Kaplan-Meier è§£æã®çµæã®è§£é
1çªç®ã®è¡¨ã¯ãåã°ã«ã¼ãã®ãã¼ã¿ã®è¦ç´ã示ãã¾ãã

ããã¦ãXLSTATã¯åã°ã«ã¼ãã«ç¹æã®çµæã表示ãã¾ããã¾ããKaplan-Meier表ã表示ããã¾ããããã¯çååå¸é¢æ°ãªã©ã®è¤æ°ã®ãã¼ã»ã¤ã³ã¸ã±ã¼ã¿ã«ã«ããKaplan-Meier è§£æã®çµæãããªãã¾ãã
 次ã®è¡¨ã¯ãå¹³åããã³ä¸å¤®å¤çåæéã¨ããããã®ä¿¡é ¼åºéã§ãã

ããã¦ãæã ã¯ä¿¡é ¼åºéã§åºåãããçååå¸é¢æ°ï¼SDFã¾ãã¯çå颿°ï¼ãå«ãè¤æ°ã®æ²ç·ãå¯è¦åã§ãã¾ãã

次ã«ãDrug 6-MP ã°ã«ã¼ãã«ã¤ãã¦çµæã®åãç³»åã表示ããã¾ãã Â
 次ã®çµæã¯ãè¨ç®ã§ããªãã£ãããã¤ãã®æ¬ æå¤ãå«ã¿ã¾ããä¸å¤®å¤çåæéã¯ãã³ã³ããã¼ã«ã»ã°ã«ã¼ãã6-MPã°ã«ã¼ããããããªãä½ã(8.667 vs 21.943)ãã¨ããããã¾ãã
SDFã§ã¯ã丸ãæã¡åããã¼ã¿ãèå¥ãã¾ãã

ããã¦ãæã ã¯2ã¤ã®ç¾¤ãæ¯è¼ã§ãã¾ããã¾ããæ¤å®ã®ç³»åã表ã«è¡¨ç¤ºããã¾ãï¼Log-rank, Wilcoxon, Tarone-Wareï¼ããã®çµæãã2ã¤ã®çå颿°ã®å·®ã¯ã¨ã¦ãææã§ãããã¨ããããã¾ ãã

æå¾ã«ã2ã¤ã®çåæ²ç·ã®æ¯è¼ã¯ãè¬ãæ£è ã®çåæéãææã«æ¹åãããã¨ã確ãããçµè«ãå¯è½ã«ãã¾ãã
 Â
Â
Was this article useful?
- Yes
- No